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Novel human papilloma virus (HPV) genotypes in children with recurrent respiratory papillomatosis

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Abstract

Introduction

Recurrent respiratory papillomatosis (RRP) is characterized by the presence of benign virally induced tumors of the larynx and respiratory epithelium that may obstruct the airway and tend to recur frequently. RRP is caused by the human papilloma virus (HPV), most frequently by HPV types 6 and 11. In this study, we present four cases of children with RRP in whom HPVs other than HPV-6 or HPV-11 were found.

Material and methods

In all four cases, HPV typing was performed by polymerase chain reaction (PCR) followed by restriction digestion (RFLP) in biopsy samples collected during surgery.

Results

In the first case, simultaneous HPV infection with types 13 and 39 was detected, while in the second case HPV-40 and HPV-56 were found. In cases 3 and 4, the biopsy samples were positive for unidentified ‘low-risk’ HPVs.

Conclusions

The presence of novel HPV genotypes in children with RRP emphasizes the need for further investigation of the implication of these genotypes in the disease.

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Abbreviations

HPV:

human papilloma virus

RRP:

recurrent respiratory papillomatosis

References

  1. Azzimonti B, Hertel L, Aluffi P, Pia F, Monga G, Zocchi M, Landolfo S, Gariglio M (1999) Demonstration of multiple HPV types in laryngeal premalignant lesions using polymerase chain reaction and immunohistochemistry. J Med Virol 59:110–116

    Article  CAS  PubMed  Google Scholar 

  2. Barr E, Tamms G (2007) Quadrivalent human papillomavirus vaccine. Clin Infect Dis 45:609–617

    Article  PubMed  Google Scholar 

  3. Bielecki I, Mniszek J, Cofała M (2009) Intralesional injection of cidofovir for recurrent respiratory papillomatosis in children. Int J Pediatr Otorhinolaryngol 73:681–684

    Article  PubMed  Google Scholar 

  4. Chesson HW, Forhan SE, Gottlieb SL, Markowitz LE (2008) The potential health and economic benefits of preventing recurrent respiratory papillomatosis through quadrivalent human papillomavirus vaccination. Vaccine 26:4513–4518

    Article  PubMed  Google Scholar 

  5. Derkay C, Darrow D (2006) Recurrent respiratory papillomatosis. Ann Otol Rhino Laryngol 115:1–11

    Google Scholar 

  6. Gallagher TQ, Derkay CS (2009) Pharmacotherapy of recurrent respiratory papillomatosis: an expert opinion. Expert Opin Pharmacother 10:645–655

    Article  CAS  PubMed  Google Scholar 

  7. Gerein V, Schmandt S, Babkina N, Barysik N, Coerdt W, Pfister H (2007) Human papilloma virus (HPV)-associated gynecological alteration in mothers of children with recurrent respiratory papillomatosis during long-term observation. Detect Prev Cancer 31:276–281

    Article  Google Scholar 

  8. Hartley C, Hamilton J, Birzgalis AR, Farrington WT (1994) Recurrent respiratory papillomatosis—the Manchester experience, 1974–1992. J Laryngol Otol 108:226–229

    CAS  PubMed  Google Scholar 

  9. Hawkes M, Campisi P, Zafar R, Punthakee X, Dupuis A, Forte V, Ford-Jones EL (2008) Time course of juvenile onset recurrent respiratory papillomatosis caused by human papillomavirus. Pediatr Infect Dis J 27:149–154

    Article  PubMed  Google Scholar 

  10. Lin KY, Westra WH, Kashima HK, Mounts P, Wu TC (1997) Coinfection of HPV-11 and HPV-16 in a case of laryngeal squamous papillomas with severe dysplasia. Laryngoscope 107:942–947

    Article  CAS  PubMed  Google Scholar 

  11. Nicollas R, Henry M, Triglia JM, Tamalet C (2007) HPV type 6 and 16 co-infection in a 11-year-old girl presenting laryngeal papillomatosis. J Clin Virol 40:252–254

    Article  CAS  PubMed  Google Scholar 

  12. Maloney EM, Unger ER, Tucker RA, Swan D, Karem K, Todd NW, Reeves WC (2006) Longitudinal measures of human papillomavirus 6 and 11 viral loads and antibody response in children with recurrent respiratory papillomatosis. Arch Otolaryngol Head Neck Surg 132:711–715

    Article  PubMed  Google Scholar 

  13. Mammas IN, Sourvinos G, Spandidos DA (2009) Human papilloma virus (HPV) infection in children and adolescents. Eur J Pediatr 168:267–273

    Article  PubMed  Google Scholar 

  14. McKaig RG, Baric RS, Olshan AF (1998) Human papillomavirus and head and neck cancer: epidemiology and molecular biology. Head Neck 20:250–265

    Article  CAS  PubMed  Google Scholar 

  15. Moore CE, Wiatrak BJ, McClatchey KD, Koopmann CF, Thomas GR, Bradford CR, Carey TE (1999) High-risk human papillomavirus types and squamous cell carcinoma in patients with respiratory papillomas. Otolaryngol Head Neck Surg 120:698–705

    Article  CAS  PubMed  Google Scholar 

  16. Morshed K, Polz-Dacewicz M, Szymański M, Polz D (2008) Short-fragment PCR assay for highly sensitive broad-spectrum detection of human papillomaviruses in laryngeal squamous cell carcinoma and normal mucosa: clinico-pathological evaluation. Eur Arch Otorhinolaryngol 265:S89–S96

    Article  PubMed  Google Scholar 

  17. Muñoz N, Bosch FX, de Sanjosé S, Herrero R, Castellsagué X, Shah KV, Snijders PJ, Meijer CJ, International Agency for Research on Cancer Multicenter Cervical Cancer Study Group (2003) Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348:518–527

    Article  PubMed  Google Scholar 

  18. Raffle AE (2007) Challenges of implementing human papillomavirus (HPV) vaccination policy. Br Med J 335:375–377

    Article  Google Scholar 

  19. Rimell FL, Shoemaker DL, Pou AM, Jordan JA, Post JC, Ehrlich GD (1997) Pediatric respiratory papillomatosis: prognostic role of viral typing and cofactors. Laryngoscope 107:915–918

    Article  CAS  PubMed  Google Scholar 

  20. Shah K, Kashima H, Polk F et al (1986) Rarity of cesarean delivery in cases of juvenile-onset respiratory papillomatosis. Obstet Gynecol 68:795–799

    CAS  PubMed  Google Scholar 

  21. Sharma G, DeHart J, Nuovo GJ (2005) Correlation of histology, human papillomavirus, and viral load in laryngeal papillomas of childhood. Diagn Mol Pathology 14:230–236

    Article  Google Scholar 

  22. Shehata B, Otto K, Sobol S, Stockwell C, Foulks C, Lancaster W, Gregoire L, Hill C (2007) E6 and E7 oncogene expression by human papilloma virus (HPV) and the aggressive behavior of recurrent laryngeal papillomatosis (RLP). Pediatr Dev Pathol 20:1

    Google Scholar 

  23. Simon M, Kahn T, Schneider A, Pirsig W (1994) Laryngeal carcinoma in a 12-year-old child. Association with human papillomavirus 18 and 33. Arch Otolaryngol Head Neck Surg 120:277–282

    CAS  PubMed  Google Scholar 

  24. Tasca RA, Clarke RW (2006) Recurrent respiratory papillomatosis. Arch Dis Child 91:689–691

    Article  CAS  PubMed  Google Scholar 

  25. Torrente MC, Ampuero S, Abud M, Ojeda JM (2005) Molecular detection and typing of human papillomavirus in laryngeal carcinoma specimens. Acta Otolaryngol 125:888–893

    CAS  PubMed  Google Scholar 

  26. Wiatrak B (2003) Overview of recurrent respiratory papillomatosis. Curr Opin Otalaryngol Head Neck Surg 11:433–941

    Article  Google Scholar 

  27. Wiatrak BJ, Wiatrak DW, Broker TR, Lewis L (2004) Recurrent respiratory papillomatosis: a longitudinal study comparing severity associated with human papilloma viral types 6 and 11 and other risk factors in a large pediatric population. Laryngoscope 114:1–23

    Article  PubMed  Google Scholar 

  28. Zur Hausen H (2002) Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2:342–350

    Article  CAS  PubMed  Google Scholar 

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Virology, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece

    Ioannis N. Mammas, George Sourvinos, Elena Vakonaki & Demetrios A. Spandidos

  2. Department of Pathology, ‘Aglaia Kyriakou’ Children’s Hospital, Athens, Greece

    Panagiota Giamarelou & Catherine Michael

Authors
  1. Ioannis N. Mammas
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  2. George Sourvinos
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  3. Elena Vakonaki
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  4. Panagiota Giamarelou
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  5. Catherine Michael
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  6. Demetrios A. Spandidos
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Corresponding author

Correspondence to George Sourvinos.

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Mammas, I.N., Sourvinos, G., Vakonaki, E. et al. Novel human papilloma virus (HPV) genotypes in children with recurrent respiratory papillomatosis. Eur J Pediatr 169, 1017–1021 (2010). https://doi.org/10.1007/s00431-010-1174-y

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  • DOI: https://doi.org/10.1007/s00431-010-1174-y

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